Progesterone decline
Falls first — often from the mid-30s. Strips your nervous system's brake. Tears, rage, insomnia, sugar cravings, broken sleep.
+ Symptom 01
Cycle · Mood · Perimenopause
When your hormones run the show.
It might be the week before your period — the version of you who picks fights, cries at ads, can't get out of bed. Or the cycle itself: cramps that send you home, bleeds that flood, breasts that aren't yours for two weeks. Or the slower shift in your late thirties and forties — broken sleep, hot flushes, brain fog, anxiety where there wasn't any.
It isn't all the same condition, but it shares the same architecture. Progesterone declining, oestrogen unclearing or swinging, cortisol compensating, thyroid wobbling, insulin shifting. Six measurable systems — we test them as one picture instead of treating the loudest symptom in isolation.
The Picture
If this is you,
it might sound like —
Read these the way you'd read a letter from someone who already knows. If three or more land hard, you're in the right place.
- I lose a week of every month — mood, energy, the lot.
- I rage or cry for no reason 7 days before my period.
- Heavy bleeds, clots, flooding, breast tenderness for two weeks.
- Cramps that send me to bed.
- PMS used to be mild. Now it's PMDD-level.
- I wake at 3am and can't get back to sleep.
- Hot flushes I never had before. Brain fog. Joint aches.
- The same workout, the same food — different result after 40.
+ Key Drivers
What we're actually looking at.
"PMS," "heavy periods" and "perimenopause" are headlines. Underneath sit six measurable systems that, once tested, explain almost everything you feel from the late luteal phase through the perimenopause transition.
Oestrogen volatility + slow clearance
Not always too much oestrogen — oestrogen the body can't clear, or oestrogen swinging wildly. Drives heavy bleeds, breast pain, mood swings, hot flushes.
Cortisol curve dysregulation
Adrenals try to compensate as ovaries step back. Chronic low-grade stress chemistry quietly worsens every other hormone.
Subclinical thyroid dysfunction
Often becomes clinical in perimenopause. A 'normal' TSH alone misses up to half the women who are under-converting T4 to T3.
Magnesium, B6 and zinc depletion
The cofactors your hormones need to behave. Without them, PMS rage and luteal-phase chaos are the default, not the exception.
Liver and gut clearance
If you can't excrete oestrogen via the bowel, you reabsorb it. Constipation is a hormone problem more often than a fibre problem.
+ Key Tests
How we find the cause — and the fix.
Not a single oestrogen reading on day 21. The full picture — across the whole cycle and decade — so the protocol fits your biology, not the average woman's.
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ENDOmap · DUTCH cycle mapWhat your hormones actually do across all four weeks. Oestrogen and its clearance pathways, progesterone, testosterone, DHEA, full cortisol curve and melatonin — collected in dried urine at home.
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Comprehensive thyroidFree T3, free T4, reverse T3, antibodies. Perimenopause is when subclinical thyroid often becomes clinical.
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HTMA · Mineral panelMagnesium, copper:zinc ratio, calcium, sodium and the trace minerals your hormones depend on. Hair tissue analysis shows what bloods hide.
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Comprehensive bloodsFasting insulin, HbA1c, full lipid panel, vitamin D, ferritin, B12, inflammation markers — the metabolic context your hormones are operating inside.
+ Foundational Must-Haves
What you can start today.
Six daily moves designed for the hormone decade. They compound — and they're protective whether you go on HRT or not.
- Magnesium glycinate 300–400 mg at bedtime. The single biggest lever for PMS rage, hot flushes, broken sleep and anxiety. Most-felt change inside 1-2 weeks.
- Protein at breakfast every day — 30 g minimum. Stabilises the blood sugar that drives the late-luteal crash and the perimenopausal energy roller-coaster.
- Strength training twice a week, non-negotiable. The #1 lever for body composition, bone density, insulin sensitivity and mood through the hormone decade.
- Hard cap on alcohol — especially in the luteal phase. Strips B6, stalls oestrogen clearance, drives hot flushes and broken sleep. The worst combination at the worst time.
- A daily bowel movement. Non-negotiable for hormone clearance. Constipation re-circulates the oestrogen you just spent two weeks producing.
- A real conversation about HRT. Not for everyone, not the bogeyman the headlines made it. We help you weigh the actual risk-benefit on your data, in conjunction with your GP.
+ The Process with How It Heals
Hormones are navigable.
You shouldn't be on an SSRI for a magnesium deficiency. You shouldn't lose a week of every month. You shouldn't be told 'just perimenopause' as if that ended the conversation. Each driver is individually testable and individually addressable.
Most clients see a measurable shift by cycle two or three on a hormone-focused reset. By month four, 'I don't feel like myself' usually isn't the daily experience anymore.
+ From the women in front of us
What changed.
Selected from clients who started here — cyclical mood collapse, heavy bleeds, perimenopausal upheaval — and worked through the 22-week reset.
I haven't cried for no reason in three months. I'd forgotten what calm felt like — I thought that part of me was gone.
A.S. · 36 · Bulimba
I've been on HRT for two months — but only because the testing made me confident it was the right call. The 22-week reset gave me my brain back.
V.S. · 44 · Telehealth